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KMID : 0904020100260020118
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Journal of Korean Society for Vascular Surgery
2010 Volume.26 No. 2 p.118 ~ p.123
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The Matrix Metalloproteinase Expression in Early Arterialized Saphenous Vein Grafts
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Huh Seung
Choi Hyang-Hee
Kim Hyung-Kee
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Abstract
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The venous wall remodeling of a vein graft that’s used in arterial bypass is the results of extensive degeneration of the extracellular matrix, and this is induced by hypertensive hemodynamic stimulation, and matrix metalloproteinases (MMPs) contribute to this partially adverse change. This study investigated the expression of MMPs in the early phase of an arterialized vein graft. Three paired great saphenous vein (GSV) segments of a pre- and post-arterialized vein graft were obtained from 3 patients with atherosclerotic arterial occlusive disease. Light microscopic examination, immunohistochemistry and zymography were performed. There is no difference between the pre- and post-arterialized GSV segments for the morphological changes of the venous walls and also on the immunohistochemistry for MMPs and TIMPs. The activities of MMP-2 and -9 were significantly increased in 2 of 3 patients. In the early arterialized phase of the vein graft, the morphological change and expression of MMPs and TIMPs were not prominent; however, MMP-2 and -9 may have some roles in venous wall remodeling.
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KEYWORD
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Vein graft, Matrix metalloproteinases
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